|
|
|
|
Of 34 eligible infants,29 were enrolled.Median age of patients was 6 months.Twenty-two infants were"symptomatic"with known or suspected cause, and seven were cryptogenic(two normal).Of 15 infants randomized to ACTH,13 responded by both EEG and clinical criteria(86.6%);seizures stopped in an additional infant,but EEG remained hypsarrhythmic(considered a failure). Four of 14 patients given prednisone responded(28.6%with complete clinical-EEG correlation),significantly less than with ACTH(X2 test).Using a prospective,randomized approach,a 2 week course of high dose ACTH is superior by both clinical and EEG criteria. |
|